PPG NUTRITIONAL, LLC
smart products
Product Overview: PPG, Proteins, DeepBlock, and Adjuvants
Among the innovative products we have developed are anti-aging solutions; metabolic regulators; restorative and modulatory products for the immune and endocrine systems; anti-inflammatory and antioxidant formulations; adjuvants designed to counteract, reduce, and eliminate drug-related side effects; exclusive products for use in pregnant women; and personalized smart foods for patients affected by different diseases, syndromes, and physiological alterations, among others presented below.
PPG PLUS Product Line:
CHOLESTEROL, LIPOPROTEINS, AND THE GREAT MODERN CLINICAL CONFUSION
In the 1950s, particularly around 1958, total cholesterol and lipoprotein values that today would be classified as “elevated” were considered physiologically normal. Average population total cholesterol levels ranged between 220 and 260 mg/dL, with estimated LDL values even higher in healthy individuals, without being automatically associated with disease. At that time, medicine was based on physiological and clinical observation rather than therapeutic cut-off points, and lipoproteins were understood as essential transport systems for cholesterol, fatty acids, fat-soluble vitamins, and hormones—not pathological agents in themselves.
Over time, modern medicine shifted this physiological approach toward a statistical and pharmacocentric model, in which isolated numerical values are treated without considering the overall biological context. The vehicle was confused with the cause, because free cholesterol is not measured—since it does not circulate in blood—but rather carrier lipoproteins, which are erroneously attributed with causing vascular damage. Current evidence, reinforced by genomics, demonstrates that cardiovascular risk does not depend on absolute LDL levels, but on processes such as chronic inflammation, oxidation and glycation of particles, endothelial dysfunction, and genetic variations that regulate their hepatic production and reuptake.
This perspective is fully consistent with the foundations of PPG PLUS, which does not seek to “normalize numbers,” but to restore and optimize physiology through intelligent nutrition, natural bioactives, and a personalized approach. From this conceptual framework, lipoproteins are indispensable biological allies whose function must be preserved and balanced—not indiscriminately suppressed. PPG PLUS therefore aligns with an integrative and evolutionary medicine, focused on correcting the real processes that damage health—inflammation, oxidative stress, and metabolic dysfunction—and on strengthening the body’s natural mechanisms to maintain longevity and quality of life.
THE PHYSIOLOGICAL ROLE OF LIPOPROTEINS
From a genomic, physiological, and biochemical standpoint, the human body is designed to biosynthesize large quantities of lipoproteins (VLDL, LDL, and HDL) under direct control of the hepatic genome. These particles are not waste products nor pathological agents per se; they are essential biological vehicles without which it would be impossible to transport:
Fat-soluble vitamins (A, D, E, and K)
Essential fatty acids
Structural and functional cholesterol
Coenzymes, steroids, and hormonal precursors, among others
A key point that is often overlooked is that free cholesterol does not circulate as such in the bloodstream. Cholesterol is a hydrophobic, intracellular structural molecule, present in membranes, mitochondria, and organelles. What clinical tests measure are carrier lipoproteins, used as indirect markers—not circulating “cholesterol” itself. This conceptual confusion has led millions of people to believe they suffer from “hypercholesterolemia,” when in reality they present physiological or adaptive increases in lipoproteins, often necessary to compensate for inflammation, oxidative stress, tissue damage, or metabolic alterations.
THE REAL PROBLEM IS LIPOPROTEIN OXIDATION, NOT THEIR PRESENCE
Lipoproteins do not cause damage by themselves. Under normal physiological conditions, they:
Are efficiently re-captured by the liver
Are effectively recycled
Participate in repair, signaling, and defense processes
Damage occurs when these particles become oxidized. Oxidation of LDL and VLDL is the central event that triggers:
Endothelial dysfunction
Chronic vascular inflammation
Atheromatous plaque formation
Platelet activation
Alteration of nitric oxide (NO) bioavailability
Among the main oxidizing agents that promote this process are:
Tobacco toxins
Excessive alcohol consumption
Synthetic sweeteners
Heavy metals
Vitamin deficiencies or excesses
Enzymatic and metabolic alterations derived from genetic polymorphisms
These factors explain why two individuals with similar LDL values may have radically different cardiovascular risks.
NOT ALL LIPID DISORDERS ARE THE SAME
Over more than 15 years of research, our scientists have confirmed that cholesterol and triglyceride alterations are not isolated diseases, but secondary manifestations of different pathological processes.
Preventing, controlling, or treating lipid disorders is not the same in:
Hypertensive patients
Cardiovascular patients
Neurodegenerative diseases
Gastrointestinal diseases
Individuals with diabetes or obesity
Patients with cancer or leukemia
Individuals with arthritis or osteoarthritis
Patients with sexual or hormonal dysfunction
Each condition has specific inflammatory, oxidative, and genetic mechanisms and therefore requires differentiated strategies.
PPG PLUS: A PATENTED RANGE OF PRODUCTS FOR PERSONALIZED LIPOPROTEIN PROTECTION
Based on these foundations, PPG NUTRITIONAL has developed, under patent, the PPG PLUS line, designed to protect lipoproteins (LDL, HDL, and VLDL) against oxidation, rather than indiscriminately suppressing them.
The different PPG PLUS formulations act on:
Reduction of systemic oxidative stress
Structural protection of LDL, HDL, and VLDL
Preservation of endothelial function
Control of platelet aggregation
Inflammatory modulation
Support of physiological nitric oxide production
Optimization of lipid metabolism according to the underlying pathology
The therapeutic key is not “lowering cholesterol,” but maintaining functional, non-oxidized, and properly recycled lipoproteins.
HEALTHY INTRACELLULAR CHOLESTEROL: A HORMONAL, IMMUNOLOGICAL, AND ANTITUMOR FOUNDATION
Healthy intracellular cholesterol is essential for:
Steroid hormone synthesis (cortisol, aldosterone, estrogens, testosterone)
Integrity of cellular and mitochondrial membranes
Maintaining high energy levels in all cells, tissues, and organs
Immune signaling
Defense responses against viruses and bacteria
Immune surveillance against cancer
Maintaining healthy male and female reproductive and sexual function
Chronic and indiscriminate suppression of cholesterol interferes with these processes and may weaken the organism’s biological resilience.
CONCLUSION
The future of lipid management does not lie in reducing numbers, but in understanding each patient’s individual biology, supported by genomic data or pathological inference. The PPG PLUS product range represents a paradigm shift, moving away from the pursuit of analytical values toward functional protection of the lipid system, based on genomics, physiology, and personalized medicine.
BIBLIOGRAPHIC REFERENCES (SCIENTIFIC SUPPORT)
- Goldstein JL, Brown MS. A century of cholesterol and coronaries. J Clin Invest. 2015.
- Ference BA et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. Eur Heart J. 2017.
- Steinberg D. The LDL oxidation hypothesis of atherogenesis. J Lipid Res. 2009.
- Libby P. Inflammation in atherosclerosis. Nature. 2002.
- Tall AR, Rader DJ. The trials and tribulations of CETP inhibitors. Circ Res. 2018.
- Kontush A, Chapman MJ. Antiatherogenic function of HDL particles. Nat Rev Cardiol. 2006.
- Ravnskov U et al. LDL-C does not cause cardiovascular disease. Expert Rev Clin Pharmacol. 2018.
- Brown AJ, Jessup W. Oxysterols and atherosclerosis. Atherosclerosis. 2009.
- Nelson DL, Cox MM. Lehninger Principles of Biochemistry. 7th ed.
- Grundy SM. Cholesterol and coronary heart disease. Circulation. 1999.
PPG PLUS PRODUCT RANGE
Based on these foundations and after several years of scientific research, we are in a position to offer a variety of patented products under the PPG Plus brand, enabling the application of personalized protocols for the prevention, control, and treatment of lipid alterations, as described below:
1) PPG Plus 9
Essential for reducing LDL cholesterol levels, preventing platelet aggregation, and promoting male and female sexual function.
2) PPG Plus AC
Essential for regulating the immune system, lowering LDL cholesterol, inhibiting cancer cell growth, and reducing cardiovascular risk; improves visual function and ocular health.
3) PPG Plus KL
Improves cardiac function, reduces inflammatory processes in internal organs, lowers LDL cholesterol, enhances concentration, memory, and learning, reduces arthritis-related symptoms, stabilizes blood sugar levels, strengthens the immune system, and improves skin health.
4) PPG Plus AO
Improves arterial function and reduces obstruction, lowers the risk of heart attacks, decreases cancer risk, controls blood glucose levels, stimulates anti-inflammatory activity, supports cognitive function, and aids digestion.
5) PPG Plus HA
Combats intestinal cancer, somnolence, and asthenia; acts as a laxative and digestive stimulant, supports pancreatic secretions, and regulates blood sugar and cholesterol levels.
6) PPG Plus AX
Modulates the immune system in children, adolescents, and adults; reduces arthritis risk; regulates triglyceride and LDL metabolism and blood pressure; improves glucose levels and insulin secretion; provides renal protection against diabetic nephropathy; prevents heart attacks and thrombosis.
7) PPG Plus CC
Prevents liver and kidney inflammation, relieves stress, helps control diabetes and cancer, reduces viral load, lowers LDL cholesterol, improves Alzheimer’s patients, helps control epilepsy and Alzheimer’s disease, reduces appetite, accelerates metabolism, and supports weight loss.
8) PPG Plus GJ
Protects against aging, increases energy and strength in individuals affected by disease, reduces body fat, lowers LDL cholesterol, improves sleep, memory, and libido recovery; has anticancer effects, enhances fertility, and strengthens muscles and bones.
9) PPG Plus SJ
Lowers LDL cholesterol, strengthens and nourishes the nervous system, increases intellectual capacity, improves memory (Alzheimer’s prevention) and cognitive function; combats insomnia and mental and physical fatigue; helps reduce cardiovascular and renal risks; prevents heart attacks.
10) PPG Plus GM
Lowers LDL cholesterol; provides skin benefits with anti-aging, antiseptic, and anti-inflammatory effects; combats sun spots, acne, and blackheads; strengthens hair and hydrates the scalp.
11) PPG Plus AN
Reduces LDL cholesterol, prevents inflammatory mediator formation, inhibits clot and thrombus formation, has vasodilatory action, regulates female hormonal effects on the menstrual cycle, and is effective in reducing ovarian cysts. Regulates nerve impulse conduction, diabetes, allergies, Alzheimer’s disease, depression, and ovarian, breast, and stomach cancer.
12) PPG Plus SM
Reduces triglycerides, lowers LDL cholesterol and blood pressure; supports atrial fibrillation management; reduces mortality risk; rheumatoid arthritis; depression.
13) PPG Plus TB
Lowers LDL cholesterol; improves blood oxygenation; helps control rheumatism and arthritis pain; protects and increases arterial flexibility; reduces tissue aging; improves psoriasis; has anti-inflammatory effects, regulates the immune system, reduces the risk of cardiac and arterial conditions, and is useful in respiratory diseases.
ADJUVANT PRODUCT LINE
Side effects and toxic reactions to medications account for approximately 15% of premature deaths in acute episodes. However, few people realize that the long-term, continuous use over years of medications prescribed for the control and treatment of hypertension, diabetes, arthritis, osteoarthritis, obesity, cardiovascular and cerebrovascular diseases, dementias, Alzheimer’s disease, and hundreds of other conditions, disorders, and syndromes often causes more harm than benefit to patients in the short and medium term.
The sustained use of medications intended to control and treat diseases, syndromes, and disorders frequently leads to the development of additional conditions, syndromes, and diseases that are generally more severe and more detrimental to quality of life than the original condition for which the medication was prescribed.
Fortunately, scientists at PPG NUTRITIONAL have applied empathic artificial intelligence methods, along with genomic and proteomic analysis, to investigate ways to counteract the adverse and toxic effects of drugs used in the management and treatment of these conditions, while simultaneously enhancing their pharmacological and therapeutic actions.
The adjuvant product line developed by PPG NUTRITIONAL is focused on reducing and eliminating the side effects of each medication used by patients to control or treat chronic diseases.
PHYSICAL ACTIVITY AND THE USE OF PERSONALIZED “BIOFUNCTIONAL PROTEINS”
A comprehensive physical activity program includes aerobic exercise, muscle and joint strengthening, flexibility, and balance. However, in many cases, individuals arrive at gyms in physical conditions that do not allow them to fully assimilate this strategy in its integral form. Therefore, it is necessary to establish approaches aimed at weight loss, obesity control, muscle strengthening, increased muscle mass, joint reinforcement, and the reduction of inflammation in these tissues, as well as minimizing the risk of injury, among other factors related to age, sex, and each person’s specific health conditions. All of this is intended to determine the most appropriate training method and the type of “intelligent” nutritional support that enables improvements in cardiovascular function and, consequently, longevity, quality of life, and the control of diseases, disorders, and syndromes.
Based on this approach, our team of scientists has worked on the development of “intelligent” protein-based nutritional supplements designed to improve metabolism and activate endogenous factors that enhance physical performance and cardiovascular function throughout the different phases of training in individuals who engage in physical activity.
The strategy of developing “intelligent” proteins based on medicinal intelligence systems has made it possible to create approximately 35 such proteins with specific purposes, tailored to the physical condition, disorders, syndromes, or diseases of individuals who systematically choose to exercise or practice sports for recreational and health-improvement purposes, as well as for athletes and sports practitioners pursuing different training objectives, such as increasing muscle mass, improving endurance, enhancing cardiorespiratory capacity, increasing muscle contraction strength, preventing lactic acid accumulation in muscle tissue, and reducing inflammatory processes associated with training and prolonged physical exertion, among others.
Scientific Basis for the Use of “Deep Block”
Scientific research into the origin, microenvironment, ecosystem, biological characteristics, incidence, and recurrence of the virus responsible for COVID-19 in different animal species was key to combining fully natural active ingredients (registered with health authorities), which enabled the development of the formulation known as “Deep Block.” This formulation has the ability to support and strengthen immune system activity, block the entry pathways of viruses, bacteria, and mites through the mouth, eyes, and nose into the lower respiratory tract, and thereby prevent the disease from progressing to severe and critical stages.
Key benefits:
* Prevents the entry of viruses and bacteria into the upper respiratory tract and oral cavity, strengthening immune defenses.
* Eliminates sore throat, tonsillar discomfort, and gum irritation.
* Promotes gum health and helps eliminate gingival bleeding.
* Helps control seasonal and environmental allergic reactions.
* Reduces inflammation caused by viruses in the lungs, heart, and brain.
* Contributes to respiratory comfort and immune balance.
* Improves and refreshes breath.
* Easy-to-use oral spray for daily immune support
In addition to controlling viral entry into the body, “Deep Block” helps minimize the cytokine storm, inflammation, the development of pro-inflammatory mediators, and promotes the elimination of free radicals (antioxidant capacity). Together, these effects help prevent the progression of alterations generated by the uncontrolled activity of the immune system. This, in turn, reduces disease progression toward severe and critical stages and death associated with the process known as disseminated intravascular coagulation.
Finally, patients who have recovered from COVID-19 also benefit, as “Deep Block” helps reduce inflammatory processes in the heart, brain, and other organs, contributing to the complete resolution of such inflammation.
Scientific Basis for the Development of “Deep Block”
Based on knowledge of the receptors to which the virus responsible for COVID-19 binds, we performed three-dimensional (3D) modeling—supported by artificial intelligence systems—of the protein domain targeted by SARS-CoV-2 and identified natural compounds capable of interfering with or blocking this binding.
However, our research went further by deepening the understanding of the evolutionary pathogenic mechanisms that drive the disease toward severe, critical, and fatal stages in infected patients. Recognizing that cytokine storms, inflammatory processes, and disseminated intravascular coagulation are the primary causes of pathological progression enabled us to select and model—using medicinal intelligence systems—which natural active compounds, in combination with other nutrients, could prevent these pathological events from occurring beyond the control of the biological mechanisms normally activated in the human body.
Scientific Basis for the Use of “Denguexoma”
EVIDENCE-BASED GENERAL DESCRIPTION
DENGUEXOMA® is a highly specialized nutritional supplement developed under the functional and intelligent nutrition framework of PPG Nutritional. It is designed to physiologically support immune response, cellular metabolism, and vascular endothelial stability in scenarios of high biological demand associated with viral infections, particularly those characterized by systemic hyperinflammation and endothelial damage, such as dengue.
Its formulation is based on a rational selection of biofunctional ingredients identified after the analysis of approximately 8,000 substances, from which five key components were prioritized. These components demonstrated modulatory, reparative, and protective effects in both in vitro and in vivo studies, acting synergistically on immunological, inflammatory, and structural processes of the vascular endothelium.
DENGUEXOMA® is intended for use in both adult and pediatric populations. Its liquid presentation optimizes bioavailability, facilitates administration, and improves therapeutic adherence in complex clinical settings.
NUTRITIONAL AND FUNCTIONAL PROPERTIES – PATHOPHYSIOLOGICAL BASIS
From a nutritional and functional standpoint, DENGUEXOMA® acts as an immunometabolic, vascular, and anti-inflammatory modulator, providing targeted support to physiological systems that are severely compromised during infectious processes characterized by:
Massive release of pro-inflammatory cytokines
Disruption of endothelial collagen
Alteration of the coagulation cascade
Systemic oxidative stress
Its functional benefits include:
Support for the normal function of the innate and adaptive immune systems, contributing to a more efficient and regulated immune response.
Contribution to the maintenance and repair of endothelial collagen, promoting the structural integrity of blood vessels affected by viral infection.
Modulation of inflammatory responses, helping to limit hyperinflammatory processes and cytokine storms.
Reinforcement of endogenous antioxidant mechanisms, reducing cellular damage induced by oxidative stress.
Support for energy metabolism and cellular function, particularly relevant during states of high physiological demand and recovery.
These effects are grounded in principles of advanced functional nutrition, based on nutrient–physiology interaction, gene modulation, and endothelial structural stability, rather than pharmacological mechanisms.
ACTIVE INGREDIENTS – FUNCTIONAL AND MECHANISTIC BASIS
Hydrolyzed Milk Peptides
A complex of bioactive peptides obtained through controlled hydrolysis, selected for their high bioavailability and their ability to participate in functional recovery processes, immunometabolic support, and inflammatory modulation.
Antioxidant and Immunological Vitamin Complex
Vitamin A: Contributes to normal immune system function and the maintenance of mucosal integrity, the first barrier against infectious agents.
Vitamin C: Supports cellular protection against oxidative stress and plays an active role in immune response.
Vitamin D: Contributes to proper immune system function and the regulation of multiple metabolic pathways.
Vitamin E: A key antioxidant that protects cellular membranes against oxidative damage induced by systemic inflammation.
Essential Fatty Acids (Omega 3, Omega 6, and Omega 9)
Essential fatty acids play a central role in maintaining cellular membrane fluidity, inflammatory balance, vascular endothelial stability, and regulation of inflammatory mediators. Their intake is critical in contexts where the body requires a controlled, efficient, and structurally reparative inflammatory response.
Plant Extracts and Biofunctional Compounds
Includes carefully selected plant-derived extracts based on their biological compatibility, antioxidant activity, and contribution to immune support, integrated within a high-precision functional nutrition model.
EXCIPIENTS AND AUXILIARY SUBSTANCES
The excipients present in DENGUEXOMA® serve essential technological functions related to the stability, preservation, and bioavailability of the active ingredients. They do not exhibit pharmacological activity.
DIRECTIONS FOR USE
Oral administration.
Suitable for adults and children.
Consume the amount indicated on the label or as directed by a healthcare professional.
Do not exceed the recommended daily dose.
PRODUCT PROFILE
Nutritional supplement for immune, metabolic, and vascular support.
Formulation oriented toward inflammatory modulation and endothelial repair.
Strategic supply of antioxidant vitamins and essential fatty acids.
Suitable for adult and pediatric use.
Liquid formulation for easy administration.
Manufactured under strict quality and control standards.
QUALITY AND SCIENTIFIC EVIDENCE APPROACH – PPG NUTRITIONAL
DENGUEXOMA® is part of the intelligent nutrition portfolio of PPG Nutritional and has been developed under criteria of biological coherence, safety, ingredient traceability, and international regulatory compliance.
The formulation is supported by:
In vitro and in vivo preclinical studies demonstrating efficacy in endothelial collagen repair and modulation of inflammatory response.
Controlled clinical trials showing high effectiveness in preventing disease progression to severe and critical stages, as well as faster recovery in patients using DENGUEXOMA® compared to controls.
Acute and chronic safety studies classifying the product as non-toxic, even after prolonged evaluations exceeding six months.
Use of artificial intelligence to model in 3D processes of endothelial structural protein repair, stabilization of the coagulation cascade, and modulation of gene expression of pro-inflammatory mediators.
BIBLIOGRAPHY – PUBLISHED CLINICAL TRIALS
Cortés RR, Cortés VH, Olazábal E, Martínez C, Collado RD, Soberanes L. (2024).
Use of DENGUEXOMA® for the Control of Severe Stages and Critical Cases of Dengue Virus: Phase II Clinical Trial.
PPG Nutritional. (Full-text available on ResearchGate; uploaded September 2024)